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KMID : 0903520060490030233
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2006 Volume.49 No. 3 p.233 ~ p.237
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Effects of Pear Extracts Cultured Under Conventional and Environment-friendly Conditions on Cell Proliferation in Rat Hepatocytes
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Yoon Byung-Chul
Kim Kil-Young
Park Soo-Hyun
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Abstract
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In the present study, we compared the functional analysis of pear extracts cultured in conventional and environment-friendly conditions in primary cultured rat hepatocytes. ATP synthesis significantly increased by the treatment with environment friendly cultured pear powder but not by conventional group. In addition, cell proliferation using [3H]-thymidine incorporation was also stimulated by environment-friendly cultured pear extract compared to conventional group. Moreover, the expressions of CDK-2 and CDK-4 were increased but p21WAF1/Cip1 and p27 Kip1 decreased by environment-friendly cultured pear extract but not by conventional group. In conclusion, environment-friendly cultured pear powder has stimulatory effect on cell proliferation compared to conventional group in primary cultured rat hepatocytes.
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KEYWORD
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Environment-friendly pear, hepatocyte, ATP, cell proliferation
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